Results displayed that HNSCC with a high T-cell inflamed phenotype (TCIP-H) were enriched in multiple immune checkpoints (particularly PD-L1, PD-L2, PD-1, TIM3, CEACAM1, LAG3, and CTLA4), had frequent mutations in CASP8, EP300, EPHA2, and HRAS, and frequent co-amplification of JAK2 and CD274. Here, EP300 is linked to head and neck squamous cell carcinoma.