HNSCC tumors with a low T-cell inflamed phenotype (TCIP-L) were enriched in the WNT/β-catenin and Hedgehog signaling pathways, had frequent NSD1 mutations, EGFR, YAP1 amplifications and CDKN2A deletions. The gene discussed is YAP1; the disease is head and neck squamous cell carcinoma.