AGT and heart failure: Conserved inhibition of VSMC proliferation and increase in vascular medial area (106, 107). Vasoconstriction and VSMC abnormalities (106, 108). Defects in heart morphology and increased hypertension with aging (106, 109). More severe heart failure with increased mortality after MI in female KO mice (106, 110). Less heart functional recovery after I/R in ERβKO female hearts compared to WT (75, 106). Loss of inhibition of Ang II-induced hypertrophy (106, 111). Conserved accelerated re-endothelialization in female mice (81, 82). Absence of atherosclerosis protection (112).