The function of GPER in adrenocortical carcinoma has been proposed to involve mitochondria-related signaling, in which GPER, via the EGR-1 pathway, positively regulates the mitochondrial apoptotic pathway via B-cell lymphoma-2-Associated X (BAX) thereby inhibiting tumor growth (114). This evidence concerns the gene GPER1 and adrenal cortex carcinoma.