Regarding the role of PAR2, several human colon cancer cell lines, namely T84, Caco-2, HT-29, and C1.19A, produce and secrete trypsin at concentrations compatible with PAR2 activation, supporting the idea of a possible autocrine/paracrine regulation of PAR2 activity by trypsin in colon cancer cells (128). This evidence concerns the gene F2RL1 and malignant colon neoplasm.