MYLK and Multiple Organ Failure: LPS recognized by TLR4 activates Src family protein tyrosine kinases (Plociennikowska et al., 2015), which in turn induces NF-κB translocation or directly activates Rock kinase and myosin light chain kinase (MLCK) signaling that causes disruption of endothelial cell junctions (Clark et al., 2015) and impairs integrity of vascular basement membrane, resulting in hyperpermeability, hemorrhage and thrombosis (Mombouli and Vanhoutte, 1999), which eventually lead to multiple organ failure, septic shock and even death (Khakpour et al., 2015).