MAPT and Alzheimer disease: The SHRSP rats have been reported to have AD like pathology with small but significant increases in hyperphosphorylated tau and Aβ, most notably vascular Aβ associated with the progressive vessel wall damage, thrombotic occlusions and reductions of cerebral blood flow in SHRSP (Bueche et al., 2014; Schreiber et al., 2014; Held et al., 2017; Pirici et al., 2017; Jandke et al., 2018).