APP and hypertensive disorder: It should also be investigated whether diminished plaques could occur directly in response to hypertension as in the mutant APP crossed onto db/db mice which have hypertension and Type II diabetes and show a slight reduction in plaques (Ramos-Rodriguez et al., 2015; Infante-Garcia et al., 2016) or result secondary to enhanced clearance from lacunar stroke and increased monocyte/macrophage invasion (Frautschy et al., 1992).