AGER and Alzheimer disease: Specifically it would be important to examine redistribution of RAGE and LRP1 between microvasculature and neurons which appears Aβ or AD specific (Donahue et al., 2006; Shang et al., 2019) and increased expression of the low-density lipoprotein receptor (LDLR) which appears hypertension or SHRSP-specific (Ueno et al., 2010).