In spite of the proven role of EMB in epilepsy related genes such as NPY, BDNF, and cAMP-responsive element-binding protein 1 (CREB_1) genes (Kundap et al., 2017a), we attempted to elucidate the overall activity of EMB to support our hypothesis by using molecular docking, immunohistochemistry, and pharmacological, biochemical, and behavioral experimentations. Here, CREB1 is linked to epilepsy.