MAPT and Alzheimer disease: The most common neurodegenerative disorder, Alzheimer’s disease (AD), is characterized by accumulation of amyloid-β peptide (Aβ) in senile plaques and hyperphosphorylated tau protein in neurofibrillary tangles (NFT) in brain, neuroinflammation, and progressive decline in cognition and memory loss finally (Price and Sisodia, 1998; Mukaetova-Ladinska et al., 2015).