Next, we studied the correlation between CSF sTREM2 levels and other AD highly associated CSF and clinical biomarkers, such as CSF tau, p-tau, Aβ42 levels, ADAS13 scores and hippocampus volumes, demonstrating that CSF sTREM2 levels were significantly positively correlated with CSF total tau and phosphorylated-tau levels for all disease status. This evidence concerns the gene MAPT and Alzheimer disease.