CACNA1C and psychiatric disorder: Although brain mitochondrial function was not affected or adaptive mechanisms were not yet exhausted in our particular risk GxE setting, i.e., Cacna1c haploinsufficiency and post-weaning social isolation, we are still convinced that mitochondria represent an important intersection point between genetic alternations, psychosocial experiences and abnormalities in cerebral energy metabolism, synaptic plasticity in psychiatric disorders (Manji et al., 2012).