On the other hand, high p62 expression induces high hexokinase 2 and hypoxia-inducible factor α expression via the upregulation of mTORC1 and NF-κB activity and the inhibition of von Hippel–Lindau E3 ubiquitin ligase activity, leading to enhancement of glycolysis in cancer [22, 23]. The gene discussed is HK2; the disease is cancer.