(4) Additionally, with the Keap1-interacting region (KIR), p62 binds to Kelch-like ECH-associated protein 1 (Keap1), leading to the activation of nuclear factor E2 related factor 2 (Nrf2), a transcription factor responsible for several antioxidant genes, which subsequently maintains a low level of ROS to protect cancer cells from oxidative damage [5, 6, 19]. Here, SQSTM1 is linked to cancer.