To verify these results, we detected the expression pattern of PADI3, Hsp90, CKS1, CDK1 and p27kip1 in colon cancer tissues and their corresponding adjacent tissues, results showed that both PADI3 and p27kip1 had lower expression level in colon cancer tissues than in the corresponding adjacent tissues. The gene discussed is PADI3; the disease is malignant colon neoplasm.