AEBP2 A198E and R388Q have been observed in kidney and oesophagus tumours, respectively.173,174 The latter mutation, located in the positively charged patch of the KR domain, potentially affects the interaction of AEBP2 with nucleosomes and, consequently, PRC2 stimulation46 (Fig. 3c). Here, AEBP2 is linked to neoplasm.