These PGD2 derivates exhibit the opposite effects on the glucose homeostasis and adipocyte differentiation involved in kidney diseases; therefore, the relationship between the diminished amount of PGD2 derivates in bio-fluids and the overexpressed tissue-specific Ptgds indicated that these PGD2 derivates elicit their lipid toxicity stimulated by accumulating in extracellular space (Figure 3F, 3G, Supplementary Table 13). The gene discussed is PTGDS; the disease is kidney disorder.