HOPX and ulcerative colitis: Using colonic sections from areas of active and inactive disease in ulcerative colitis subjects, we found expression of Hopx, as well as regenerative epithelial markers Tacstd2 and Msln (Gregorieff et al., 2015), were detected in hypertrophic crypts within the inflamed areas but not in uninflamed areas (Figure S1F), suggesting a similar paradigm of regeneration may occur in human colon.