INS and Hypoglycemia: When diazepam and insulin were applied together with diazepam, they rescued GABA-evoked currents of mutant R214C GABAARs to 80.9% of WT GABAARs. This suggests that diazepam and insulin work synergistically and could theoretically be a more effective strategy for patients with the R214C variant, but there are practical obstacles to using insulin as an anti-seizure medication given its potent adverse effect of hypoglycemia.