Conversely, for patients with established RA from DE019 and ARMADA who were continuing background MTX, lower ACR responses for both the lowest P value and the greatest treatment difference were more discriminatory when comparing PBO+MTX versus ADA+MTX; ACR35 and ACR30 for DE019 and ARMADA respectively, at week 24 (Fig. 1c, d and Additional file 1: Table S1). This evidence concerns the gene ADA and rheumatoid arthritis.