An interesting difference between NPC1 and Tangier was the lack of efficacy of HPβCD in Tangier patient fibroblasts as it is very effective in the treatment of NPC disease animal models and corrects NPC cells.35 Previous studies reported that cholesterol storage could not be depleted in Tangier cells following HPβCD treatments,20 in line with our findings. This evidence concerns the gene NPC1 and nasopharyngeal carcinoma.