Interestingly, ABCA1 has been implicated to act as a sphingosine‐1‐phosphate exporter,31, 32 and studies have suggested that cholesterol efflux via ABCA1 is regulated in part by sphingosine kinase.33 Although the mechanism leading to elevated levels of sphingosine in Tangier disease remains unknown, it is plausible that sphingosine storage is a direct consequence of mutations in ABCA1 considering the interrelationship between ABCA1, sphingosine kinase, and spingosine‐1‐phosphate.32, 33. This evidence concerns the gene ABCA1 and Tangier disease.