NR1H3 and atherosclerosis: Different CLA isomers have been demonstrated to have different, and sometimes opposite, effects on the host: c9,t11-CLA improves insulin sensitivity and decreases atherosclerosis by activation of proliferator-activated receptor γ (PPARγ), t10,c12-CLA worsens insulin sensitivity and atherosclerosis by inhibiting expression of PPARγ and LXRα [21–23], and t9,t11-CLA reduces atherosclerosis by activation of LXRα [24].