There also existed a drastic expansion of interferon γ (IFNγ)-producing CD4+ T helper cells (Th1) cells (CD4+IFNγ+Th1 cells) and NKp46+ IFNγ+ cells in the LP tissues of DSS-mediated colitis and E. coli O160:H7-colonized mice (Figures 3B–3D). This evidence concerns the gene IFNG and colitis.