As it grows fast, it is often assumed to represent a malignant process, such as a squamous cell carcinoma (SCC), a CD30 positive lymphoproliferative disorder (LPD), or an infectious disease, such as primary syphilis, tuberculosis, or Epstein-Barr virus (EBV)-associated mucocutaneous ulcer [5]. Here, TNFRSF8 is linked to infectious disease.