Thus, in a subset of HCC cases, GPC3 may interact with MCT4 and GLUT4 on the cell surface and facilitate their functions, allowing HCC cells to easily adapt to hypoxic microenvironments and accelerate the invasive phenotype with CD147, an inducer of matrix metalloproteases frequently co-existing with MCT4 [13–15]. This evidence concerns the gene GPC3 and hepatocellular carcinoma.