Individuals with T2DM and prior ASCVD are classified as being at extreme risk by the American Association of Clinical Endocrinologists (AACE), who recommend LDL-C targets of < 55 mg/dL, non-HDL-C targets of < 80 mg/dL, and ApoB targets of < 70 mg/dL for this patient population [19]. The gene discussed is APOB; the disease is atherosclerosis.