For examples, the copy number amplification and expression level upregulation of FYTTD1 and CTTN would remarkably cause a poor prognosis in tumor patients of ESCA and head and neck squamous cell carcinoma (HNSC) respectively (Fig. 5b), while the copy number deletion and expression level downregulation of MTAP was significantly associated with a worse prognosis (Fig. 5b). The gene discussed is CTTN; the disease is head and neck squamous cell carcinoma.