Finally, a set of robust prognostic signatures including SYCN, PNLIPRP1, CAP2, GNMT, MAT1A, ABAT, GPT2, ADHFE1, PHGDH, PSAT1, ERP27, PDIA2, MT1H, COMP, COL5A2, FN1, COL1A2, FAP and POSTN were identified by lasso regression analysis from DEGs and could diagnose the PC. Here, COL5A2 is linked to pachyonychia congenita.