Western blot analysis revealed that treating ENMD-2076 for 24h increased the expression of Cleaved Caspase-3 and Bax in LN18, T98G cells as well as decreased the expression of anti-apoptotic Bcl-2 and thereby inducing glioblastoma cells apoptosis, the ratio of Bax/Bcl-2 increased in a dose-manner (Figure 7D). The gene discussed is BCL2; the disease is glioblastoma.