PPA2 and cardiomyopathy: Given that the incidence of “severe” childhood cardiomyopathy is ~0.50 per 100,000 population under the age of 10–15 years, the estimated the incidence of cardiomyopathy due to PPA2 biallelic variants would be approximately 0.01 per 100,000 (1 per 10,000,000) pediatric population (Vasilescu et al., 2018).