MT‐ND3, MT‐ND4, MT‐ND4L, MT‐ND5 and MT‐ATP8) and genes involved in signal transduction, carcinogenesis, immune system, endocrine system, nervous system etc (Results further revealed differential expression of genes involved in various systems, including MT‐ND2) Our discovery is likely to provide new insights to molecular mechanisms of Wuzang Wenyang Huayu regarding hippocampal transcripts in a murine vascular dementia model. This evidence concerns the gene MT-ND4L and vascular dementia.