The genomic structure of NCF1 region is extremely complicated due to presence of two pseudogenes highly homologous to NCF1. Two recent studies performed careful association analysis of the GTF2I-NCF1 region with SLE, and reported that a missense mutation in NCF1, rs201802880, may be the primarily associated variant in this region10,11. The gene discussed is NCF1; the disease is systemic lupus erythematosus.