Conversely, Yy1 (FS = 16.39 ± 1.44%, n = 5, P = 1.26E-03) significantly improved cardiac performance of Ttn transduced mice compared to those treated with EGFP control (FS = 9.91 ± 4.32%, n = 20).We further assessed the suppressive effect of Yy1 on DCM induced by Ttn shRNA for three additional timepoints (Fig. 2A,B, Supplementary Table S3). This evidence concerns the gene TTN and familial dilated cardiomyopathy.