In addition, progressive VED injury significantly increased the transcription of complement factor-H (Cfh), C2 complement (C2), Fc fragment of immunoglobulin G receptor-IIb (Fcgr2b), and interferon-induced protein with tetratricopeptide repeats 1B-like (Ifit1bl), genes related to pathogen infection processes (Supplementary Figure 4). Here, CFH is linked to familial isolated deficiency of vitamin E.