Since RhoA knockdown tumors with significant CAFs and TAMs infiltration showed relatively increased lymph node and lung metastases formation, it is therefore possible that reduced RhoA activity in tumor cells promotes its metastatic dissemination by activating both the CXCL12-CXCR4 and CCL5-CCR5 signaling pathways. Here, CXCR4 is linked to neoplasm.