Activated fibroblasts in tumor stroma are termed cancer-associated fibroblasts (CAFs), which are generally pro-tumorigenic with a dynamic and complex secretory phenotype including ECM molecules (tenascin C, collagen), growth factors (VEGFA, PDGF, HGF), cytokines, and chemokines (TNF, IFNγ, CXCL12, CCL5, IL-6, IL-8)24. Here, HGF is linked to neoplasm.