ABCC6 and endothelial dysfunction: DOCA-salt model engenders CV remodelling that is representative of human volume-overload-induced AHT, involving vascular inflammation, hypertrophy, endothelial dysfunction and fibrosis13 Despite DOCA-salt model was reported to cause heart dysfunction witnessed by diastolic blood pressure (DBP) impairment23, we observed no differential effect of Abcc6−/− genotype on DBP or heart rate (HR).