ABCC6 and Myocardial fibrosis: In the present study, we evidence that DOCA-salt-induced AHT gives rise to profound CV remodelling in Abcc6−/− mice which was associated with (i) calcium deposits in the heart characteristic of DCC; (ii) myocardial fibrosis; (iii) extensive vascular fibrosis and (iv) vascular gene expression involved in calcification and fibrosis.