However, like the basal-like tumors from Tg-C3T and p53+/−;Brca1−/− mice, GATA3 and ERα was barely detectable in tumor primary cultures from Tg-EZH2T416D and Tg-Neu;EZH2T416D mice even after long exposure (Fig. 1e, lanes 2–3). Here, ESR1 is linked to neoplasm.