Using both basal-like (CK14) and luminal (CK18) markers, we examined the tumor tissues from Tg-EZH2T416D mice by IHC and observed CK14-positive and CK18-negative staining (Fig. 1b, left), similar to that in p53−/+;Brca1−/− tumors, which are representative of basal-like tumors (Fig. 1b, right). This evidence concerns the gene TP53 and neoplasm.