Compared with the T47D-vector control cells, EZH2T416D-expressing tumor from the xenograft mouse model, along with EZH2T416D-expressing stable cell line and EZH2T416D tumor-derived cell lines (p6 and p8) displayed basal-like phenotype as indicated by the decrease in ERα, CK18, and GATA3 and increase in CK14 (Supplementary Fig. 2c). The gene discussed is ESR1; the disease is neoplasm.