CACNA1E and Parkinson disease: To do this, we compared neuronal viability in wildtype and Cav2.3 knockout mice, subjected to chronic low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/probenecid treatment, which is still the standard model for preclinical testing of neuroprotective Parkinson’s disease therapies in animals45,46.