CD8A and neoplasm: In addition to enhancing APC sensing of immunogenic IR at irradiated tumor sites and cross-presentation of TAs to prime effector T cells at TDLNs, inhaled NP-cGAMP promotes proinflammatory TME in non-irradiated tumors and facilitates recruitment of cytotoxic CD8+ T cells, which contribute to robust anticancer immunity observed in this study (Fig. 1a).