PRPH2 and Behcet disease: Dysregulation of this function, in part due to an alteration in the adhesiveness of the interphotoreceptor matrix to the RPE, results in the vitelliform deposition seen in BD.55–58 Variants in other genes can also result in a similar vitelliform phenotype as seen in BD, including PRPH2, IMPG159 60 and IMPG2. 59