During diethylstilbestrol treatment capillaries became more tortuous with increased calibre and developed haemorrhage areas, suggesting a possible role for M2-macrophages in angiogenesis and vasculature modulation in PitNETs [21], in agreement with our observed correlations between CD163:HLA-DR macrophage ratio and PitNET microvessel density and area. This evidence concerns the gene CD163 and hemorrhage.