NF-PitNETs secreted higher amounts of cytokines/chemokines than somatotropinomas, especially CCL2 (16x more), IL-8 (25x more) and CCL4 (27x more), except for FGF-2 which was found in higher concentrations in somatotropinoma supernatants (Fig. 1b). This evidence concerns the gene FGF2 and growth hormone-producing pituitary gland neoplasm.