LCOs have been used previously for ex-vivo staining on human and mouse brain tissue by fluorescence microscopy and have been found to label NFTs (i.e. fibrillary tau, but no soluble tau, [5]), and Aβ plaques and cerebral amyloid angiopathy (CAA) at high contrast and specificity [6]. Here, MAPT is linked to cerebral amyloid angiopathy.