In addition, MAC, SRCC, and AM, were significantly associated with some features of aggressiveness, including poor tumor differentiation, large size of primary tumors, high level of carcinoembryonic antigen (CEA), advanced T stage and N stage, distant metastasis, high positive rates of circumferential resection margin (CRM) involvement, and perineural invasion, as well as frequent presence of tumor deposits (all P <  0.001, Table 2, P1 using “CA” as the reference). This evidence concerns the gene CEACAM5 and neoplasm.