AQP9 expression was also significantly higher in ccRCC primary tumors in comparison with adjacent normal tissues in GSE11151 (Yusenko Renal dataset; ***p < 0.001) [29], GSE14994 (Beroukhim Renal dataset; *p < 0.05) [30] and GSE6344 (Gumz Renal dataset; *p < 0.05) [31] (Fig. 1b–d). The gene discussed is AQP9; the disease is nonpapillary renal cell carcinoma.