In addition, Hoxa9 and Mzf1 involved in development of myeloid leukemia were up-regulated [31, 32], while genes associated with differentiation, including Pax5 and Sox4, were down-regulated in both DKI and Dnmt3aR878H/+ groups [33, 34] (Fig. 5d). The gene discussed is SOX4; the disease is myeloid leukemia.