Compared with Dnmt3aR878H/+ mice and NrasG12D/+ mice, DKI mice showed obvious up-regulation of transcription factor Myc and a serial of Myc target genes [35], including Nme family genes, Cebpa, Npm1 and Bcl3 genes involved in the development of leukemia [36–38], Cdk4 and Bax genes related with cell cycle and apoptosis process [39, 40]. The gene discussed is CDK4; the disease is leukemia.