Besides, a previous report showed co-expression of DNMT3A R882H and NRAS G12D could induce mouse AML by using a retroviral transduction system, in which the expression of mutant DNMT3A and mutant NRAS were driven by a retroviral promoter instead of the endogenous promoter/enhancer [12, 25].. Here, DNMT3A is linked to acute myeloid leukemia.