Among the factors that link obesity to carcinogenesis are the activation of the insulin/IGF-1 pathway, increased concentrations of pro-inflammatory cytokines (TNF-α, IL-1 and IL-6) and their influence on adipocytokines [2], and dyslipidemia, which is often associated only to obesity [3]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.