AIF1 and Alzheimer disease: However, there was a significant increase for Iba1 and P2RY12 in iAD compared to AD cases: Iba1: AD = 0.29% (IQR: 0.13–0.68%) vs iAD = 0.87% (IQR: 0.40–1.11%), P = 0.036; P2RY12: AD = 0.09% (IQR: 0.00–1.09%) vs iAD = 0.60% (IQR: 0.50–1.08%), P = 0.041 (Fig. 3).