To validate the clinical implication of liver stiffness, we analyzed clinicopathologic data of 74 HCC patients in our hospital and found that higher liver stiffness was not only correlated with gender, albumin, conjugated bilirubin, AST, GGT, and Metavir’s G grade and S grade significantly, but more importantly closely associated with poor tumor differentiation (P = 0.026) and higher HCC recurrence (P = 0.036) (Table 1), demonstrating that increased liver stiffness promotes a loss of tumor differentiation and higher recurrence. This evidence concerns the gene ALB and hepatocellular carcinoma.