The pathogenic variants detected in the pre-treatment scalp melanoma included the BRAF-V600E mutation (BRAF c.1799 T > A, p.V600E), amplification of BRAF located on chromosome 7q34, and loss of the tumor suppressor gene CDKN2A located on chromosome 9p21.3 (Fig. 3a). Here, CDKN2A is linked to melanoma.