Furthermore, miR-92a can negatively regulate the expression of atherosclerosis protection factors krüppel-like factor 4 (KLF4) in arterial endothelium, and knock-down of miR-92a can partial reduce expression of proinflammatory markers such as monocyte chemotactic protein 1, vascular cell adhesion molecule-1, E-Selectin and endothelial nitric oxide synthase in vitro, which was attributable to increased KLF4 expression [32]. Here, KLF4 is linked to atherosclerosis.