Mice deficient in the ability to synthesise a-series gangliosides (genetic deletion of B4GALNT1, encoding GM2 synthase), specifically GM1a, develop parkinsonism, including the loss of TH-positive cells, lower striatal dopamine levels, an accumulation of α-synuclein aggregates and impaired motor function [39]. Here, B4GALNT1 is linked to Parkinsonism.