Germline EGFR mutations are very rare, less than 1/7500 (0.01%) in the general population [40]; the proportion is higher in sporadic lung cancers, namely 1/555 (0.18%) of lung ADCs from TCGA (mostly White) [65] and 14/12,833 (0.11%) of Chinese lung cancers [66]. The gene discussed is EGFR; the disease is lung carcinoma.