EGFR and lung cancer: There was a significantly higher proportion of EGFR mutation in patients with family history of lung cancer (FHLC) than those without (OR = 1.53[1.18–1.99], P = 0.001) (Fig. 3a), including in analyses limited to those who had lung cancer in their first degree relatives (OR = 1.76 [1.36–2.28], P < 0.0001) (Fig. 3a).