EGFR and lung cancer: It’s of note, EGFR-mutated lung cancers generally have a different epidemiological profile from the EGFR wild-type ones, the former more likely to be non-smokers (vs smokers: 37.6%~ 62.5% vs 8.4%~ 35.9% varying by ethnicity), East Asians (vs Westerns: 47.9% vs 19.2% in ADCs) and lung adenocarcinomas (vs SCCs: 47.9% vs 4.6% in Asians) [20–22], which may indicate distinct modulations of relevant variables in tumorigenesis.