NFKB1 and hepatocellular carcinoma: Also, those stably transfected HCC cells were transfected with a NF-κB-dependent luciferase reporter plasmid together, and assays of luciferase activity in lysates showed that knockdown of Aurora-A reduced NF-κB activity in radioresistant HCC cells and upregulation of Aurora-A increased the activity in their parental cells, while compared with control cells (Fig. 6f).