NFKBIA and hepatocellular carcinoma: Next, we determined the effects of Aurora-A expression on the expression of p65 and IκBα in HCC cells, and demonstrated that knockdown of Aurora-A could result in the increased expression level of nuclear IκBα protein and the decreased expression of nuclear p65 protein in HepG2-R cells (Fig. 6d) and upregulation of Aurora-A could result in the decreased expression level of nuclear IκBα protein and the increased expression level of nuclear p65 protein in HepG2 cells (Fig. 6e).