G6PD and HIV infectious disease: More so, HIV infection on its own may play vital role through the production and release of HIV-TAT (trans-acting transcriptional activator), [31] since TAT blocks transcription of manganese superoxide dismutase [32], an enzyme that helps to prevent oxidative stress and as well markedly decrease the activity of glucose-6-phosphate dehydrogenase, [21, 33] a key enzyme in pathway that maintain GSH in its reduced state.